display: inline-block; Thank you so much for your assistance, Chris. (The Y chromosome is the other sex chromosome.) margin-top: 40px; In JavaScript, function parameters default to undefined. margin-bottom: 20px 2012 Feb;97(2):129-34. doi: 10.1136/adc.2010.189092. FMR1 Disorders. Typically, the parents of an individual with an autosomal recessive condition each carry one We recognise that many of the outcomes are related. How can you know the sky Rose saw when the Titanic sunk? ifelse . My work as a freelance was used in a scientific paper, should I be included as an author? .page--our-work .region-content .paragraph--type--quick-links { To subscribe to this RSS feed, copy and paste this URL into your RSS reader. SyntaxError: Unexpected '#' used outside of class body, SyntaxError: unparenthesized unary expression can't appear on the left-hand side of '**', SyntaxError: Using //@ to indicate sourceURL pragmas is deprecated. JavaScript is disabled. MedlinePlus also links to health information from non-government Web sites. } They are basically in chronological order, subject to the uncertainty of multiprocessing. Sep;45(6):1042-53. doi: 10.1111/j.1469-7610.2004.t01-1-00297.x. } 10.1097/MOP.0b013e32833b7a69. More specifically, in 20222023 weve decided to exclusively support heritage projects that lead to one of six priority outcomes, which are especially important during the current pandemic. Achondroplasia is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. We do not currently allow content pasted from ChatGPT on Stack Overflow; read our policy here. } .book-navigation-present .img-responsive { Epub 2020 Jan For example, you can create a policy that uses the aws:CurrentTime background-image: -ms-linear-gradient(top, #ededed 5%, #dfdfdf 100%); CertainTeed offers you the broadest range of color and style choices. } } confusion between a half wave and a centre tapped full wave rectifier, followed by 1 through 8, and any number of additional digits. How are genetic conditions treated or managed? Usually, males are more severely affected by this disorder than females. In the following example, if no value is provided for b when multiply is called, b's value would be undefined when evaluating a * b and multiply would return NaN. 10.1055/s-0031-1280915. background-size: 200% 100%; The abnormally expanded CGG segment turns off (silences) the FMR1 gene, which prevents the gene from producing FMRP. In the remaining cases, people with achondroplasia have inherited an altered FGFR3 gene from one or two affected parents. Ah, no, I see what the issue is. Clinical management of achondroplasia. To search for records by Created/Published/Temporal Extent Period use the 'Date Range' option. importance: 3. 2002 .field--type-text-with-summary h2 { However, it's often useful to set a different default value. } /* Content feedback */ Contact a health care provider if you have questions about your health. ul.dropdown-menu li { Some children with an FMR1 premutation may have learning disabilities or autistic-like behavior. operator, SyntaxError: redeclaration of formal parameter "x". color: #000; Asserts that expected and actual iterables are deeply equal.. If yes, to do something; otherwise, something else. Big Blue Interactive's Corner Forum is one of the premiere New York Giants fan-run message boards. Hunter JE, Berry-Kravis E, Hipp H, Todd PK. But youll see its not style over substance. Wright MJ, Irving MD. margin-bottom: 20px If the condition is false, another block of code can be executed. National Organization for Rare Disorders (NORD). MedlinePlus links to health information from the National Institutes of Health and other federal government agencies. fragile X-associated tremor/ataxia syndrome: two faces of FMR1. Most cases of congenital hypothyroidism are sporadic, which means they occur in people with no history of the disorder in their family. } You can use the Condition element of a JSON policy to test specific conditions against the request context. When inherited, the condition usually has an autosomal recessive inheritance pattern, which means both copies of the gene in each cell have mutations. In: Adam MP, Everman DB, Mirzaa GM, Pagon RA, Wallace background-image: -o-linear-gradient(top, #ededed 5%, #dfdfdf 100%); Mutations in the FMR1 gene cause fragile X syndrome. editors. What happens if you score more than 99 points in volleyball? text-align:center; padding-left: 40px; great algo either way thanks! /* Blockquote padding hotfix */ An outcome is a result of what your project does. In some cases, however, individuals with a premutation have lower than normal amounts of FMRP. In: Adam MP, .alert-success { } /* Post re-theme heading amends */ Protect your children from lead where they learn and play: learn how to test your child, and how to check the condition of schools and child care facilities; How schools and child care centers can test for lead in drinking water; Drinking Water Requirements for Lead EPA's Drinking Water Regulations for Lead Cartilage is a tough but flexible tissue that makes up much of the skeleton during early development. padding-left: 15px; are deprecated, SyntaxError: "use strict" not allowed in function with non-simple parameters, SyntaxError: "x" is a reserved identifier, SyntaxError: a declaration in the head of a for-of loop can't have an initializer, SyntaxError: applying the 'delete' operator to an unqualified name is deprecated, SyntaxError: cannot use `? Much has been made of the role of the operators in the Chernobyl accident. Washington, Seattle; 1993-2022. font-weight: 700; See our, URL of this page: https://medlineplus.gov/genetics/condition/achondroplasia/. Fragile X syndrome: diagnostic and Fragile X syndrome is a genetic condition that causes a range of developmental problems including learning disabilities and cognitive impairment. The [sum_range] is the range where the Ready to optimize your JavaScript with Rust? Why do you have to clearly set out your project outcomes? } .region-content article.video. Epub Curr Opin Pediatr. padding-right: 20px; color: #2f789f; Each invocation of iteratee is called with three arguments: (element, index, list).If list is a JavaScript object, iteratee's arguments will be http://www.ncbi.nlm.nih.gov/books/NBK1152/. () JavaScript . The range is 0.001-0.009. The easiest way of describing an outcome is to explain how it is different from an output. U.S. Department of Health and Human Services, X-linked mental retardation and macroorchidism. The iteratee is bound to the context object, if one is passed. Tutorials, references, and examples are constantly reviewed to avoid errors, but we cannot warrant full correctness of all content. } Is it appropriate to ignore emails from a student asking obvious questions? Fingers are typically short and the ring finger and middle finger may diverge, giving the hand a three-pronged (trident) appearance. The information on this site should not be used as a substitute for professional medical care or advice. And if you are clear about your outcomes, but they dont line up with one of the priority outcomes, we also won't be able to help you. Erratum In: Pediatrics. width: auto; In the function, the base condition is that if the length of the string is equal to 0, the string is returned. color: #595959; font-family: "Effra Bold", "Arial", sans-serif; Males and females with 55 to 200 repeats of the CGG segment are said to have an FMR1 gene premutation. Join the discussion about your favorite team! A JSON null value is converted to an SQL null in all cases. } padding-right: 35px; future treatment. Why was USB 1.0 incredibly slow even for its time? Sure, you just end up testing both of your input times against the lower bound, then both of them against the upper bound. Most males and about half of females with fragile X syndrome have characteristic physical features that become more apparent with age. padding-top: 10px; J Child Psychol Psychiatry. border-color: #2f789f; Achondroplasia is the most common type of short-limbed dwarfism. caption { Pediatrics. Check if a value is within a range of numbers. So if it's 5:05 PM in A1 and 6:01 PM in B1, value is true. text-decoration: none; Visit Mozilla Corporations not-for-profit parent, the Mozilla Foundation.Portions of this content are 19982022 by individual mozilla.org contributors. 2006 Jan-Feb;49(1):1-8. doi: 10.1016/j.ejmg.2005.11.001. . What does "use strict" do in JavaScript, and what is the reasoning behind it? Am J Med Genet A. Mutations in the FGFR3 gene cause achondroplasia. .book-navigation-present .img-responsive font-size: 16px; Sherman S, Pletcher BA, Driscoll DA. .agree-button { The UNs SDG Moments 2020 was introduced by Malala Yousafzai and Ola Rosling, president and co-founder of Gapminder.. Free tools for a fact-based worldview. Individuals who inherit two altered copies of this gene typically have a severe form of achondroplasia that causes extreme shortening of the bones and an underdeveloped rib cage. Find centralized, trusted content and collaborate around the technologies you use most. greeting, if not, but time is less than 20:00, create a "Good day" greeting, The Excel team increased the size of the grid in 2007. Code Please focus on the outcomes that are strongest for your project, as we will monitor your progress against these and you will use them to evaluate the change your project has made. transition: background 500ms ease-in-out, color 500ms ease-in-out, border-color 500ms ease-in-out, top 500ms ease-in-out, right 500ms ease-in-out, bottom 500ms ease-in-out, left 500ms ease-in-out, margin 500ms ease-in-out, padding 500ms ease-in-out; fragile X-associated primary ovarian insufficiency, fragile X-associated tremor/ataxia syndrome, Genetic Testing Registry: Fragile X syndrome, National Organization for Rare Disorders (NORD). border-radius: 0px; text-decoration: underline; executed if the condition is false: The else if statement specifies a new condition if the color: white; Horton WA. Seizures occur in about 15 percent of males and about 5 percent of females with fragile X syndrome. Can we keep alcoholic beverages indefinitely? The conditions are referred to as criteria1, criteria2, and so on, which can check things like:. In all non-legacy browsers, undefined is a non-configurable, non-writable property. max-width: 100%; Two specific mutations in the FGFR3 gene are responsible for almost all cases of achondroplasia. content: ""; I never claimed it to be whatever you imagined yourself it is. Available from stroke:#2f789f; We expect projects to achieve some outcomes more strongly than others. Genet Med. This operator is frequently used as an alternative to an ifelse statement. By clicking Accept all cookies, you agree Stack Exchange can store cookies on your device and disclose information in accordance with our Cookie Policy. { 2020 Mar;136:104740. doi: 10.1016/j.nbd.2020.104740. Won't somebody PLEASE think of the time complexity!? Fragile-X syndrome and 2007 Jan;53(1):27-38. doi: /* Signpost w book image fix */ How to check whether a string contains a substring in JavaScript? h2.field--name-field-item-title { If yes, to do something; otherwise, something else. Your coding is good but it doesn't fit the question, that's all. if else if else if else . Available from Why would Henry want to close the breach? background-image: -webkit-linear-gradient(top, #ededed 5%, #dfdfdf 100%); As a result, they may have mild versions of the physical features seen in fragile X syndrome (such as prominent ears) and may experience emotional problems such as anxiety or depression. Connect and share knowledge within a single location that is structured and easy to search. } In some cases, it can make sense to use an assignment as a condition but when you do, there's a right way to do it, and a wrong way; the while documentation has a Using an assignment as a condition section with an example showing a general best-practice syntax you should know about and follow. But first, lets see what happens with boolean values. this will work: If you're already using lodash, you could use the inRange() function: By contrast, the premutation in men does not expand to more than 200 repeats as it is passed to the next generation. /* Hide social media svgs in footer */ Recent milestones in achondroplasia research. The fragile X syndrome: from aspphpasp.netjavascriptjqueryvbscriptdos 2011 Jul;29(4):299-307. doi: padding-left: 40px; insufficiency. Tassone F, Gantois I, Sonenberg N, Mandel JL, Hagerman PJ. /* Hub filter label font increase */ How do I check whether a checkbox is checked in jQuery? #block-fundingbeforeyoustart > div:nth-child(2) > div:nth-child(1) > ul:nth-child(2) Because we pass in the range object, inside the isInRange() function, the this keyword references to the range object. How do I arrange multiple quotations (each with multiple lines) vertically (with a line through the center) so that they're side-by-side? Semin Reprod Med. } Am J Med Genet C Semin .book-navigation-present .search-result-right Help us to understand what website content people are interested in. Affected individuals usually have delayed development of speech and language by age 2. list-style: inside; How can gene variants affect health and development? Overall, the risk of developing this condition is greater for first-degree relatives of affected individuals (such as siblings or children) as compared to the general public. SE, Bean LJH, Gripp KW, Amemiya A, editors. SyntaxError: test for equality (==) mistyped as assignment (=)? .erd-list--social-media svg.ext { About 80 percent of people with achondroplasia have average-size parents; these cases result from new mutations in the FGFR3 gene. border-style: solid; Check the range outside. vertical-align: middle; In women, the FMR1 gene premutation on the X chromosome can expand to more than 200 CGG repeats in cells that develop into eggs. I want to check if a value is in an accepted range. Epub 2006 Jul 17. Loss or a shortage (deficiency) of this protein disrupts nervous system functions and leads to the signs and symptoms of fragile X syndrome. h1 { I know how to use multiple if to check this, but I want to know if there is any way to check it in a single if statement. Spinal stenosis is associated with pain, tingling, and weakness in the legs that can cause difficulty with walking. 2007 Jul { } font-size: 18.66px; Hagerman RJ, Berry-Kravis E, Hazlett HC, Bailey DB Jr, Moine H, Kooy RF, } Is there a higher analog of "category with all same side inverses is a groupoid"? { Everman DB, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, Usually, males are more severely affected by this disorder than females. Collection Functions (Arrays or Objects) each_.each(list, iteratee, [context]) Alias: forEach source Iterates over a list of elements, yielding each in turn to an iteratee function. font-size: 18px; Thank you Chris, you have no idea how much time you have saved me. ifelse . 2006 Jan 15;140(2):166-9. doi: 10.1002/ajmg.a.31029. I have a new question on this same subject. font-size: Change the value of the source attribute (src) of an element, if the user clicks on the image: JavaScript Tutorial: JavaScript IfElse Statements, JavaScript Tutorial: JavaScript Switch Statement. Characteristic features of achondroplasia include an average-size trunk, short arms and legs with particularly short upper arms and thighs, limited range of motion at the elbows, and an enlarged head (macrocephaly) with a prominent forehead. The if/else statement is a part of JavaScript's "Conditional" Statements, which are used to perform different actions based on different conditions. The 1986 Summary Report on the Post-Accident Review Meeting on the Chernobyl Accident (INSAG-1) of the International Atomic Energy Agency's (IAEA's) International } /* Video CT CTA button look and feel */ How to see if number is "between" values? The outcome is happier, wiser students who are more able to succeed. Affected individuals usually have delayed development of speech and language by age 2. Horton WA, Hall JG, Hecht JT. Med Genet. .decline-button eu-cookie-compliance-default-button { What does it mean if a disorder seems to run in my family? You can help keep this site running by allowing ads on MrExcel.com. } condition exprIfFalse . Up to the end of financial year 20222023, were prioritising heritage projects that will meet six of our outcomes as a response to the COVID-19 pandemic. Achondroplasia is a form of short-limbed dwarfism. Legare JM. Outcomes are changes, impacts or benefits that happen as a direct result of your project. .toc-link { If the output column is a composite (row) type, and the JSON value is a JSON object, the fields of the object are converted to columns of the output row type by recursive application of these rules. Achondroplasia. Its a change that happens, rather than an activity or service you provide (which are outputs). background-color: #ededed; fibroblast growth factor receptor 3 disorders: the achondroplasia family of background-image: -webkit-gradient(linear, left top, left bottom, color-stop(5%, #ededed), color-stop(100%, #dfdfdf)); How can gene variants affect health and development? The word achondroplasia literally means "without cartilage formation." If the values are strings, they will be encoded as utf-8 and kept as Uint8Array[].If the values is a WebGLData object, the dtype could only be 'float32' or 'int32' and the object has to have: 1. texture, a WebGLTexture, the line-height: 1em; /* Funding block list style */ margin-top: 1em; The inheritance is dominant if one copy of the altered gene in each cell is sufficient to cause the condition. If you must use a regexp (and really, you shouldn't!) .region-content article.video ul { If it's 5:25 in A1 and 5:26 PM in B1, value is still true. 2010 Aug;22(4):516-23. doi: We cant support projects that dont connect people and communities to heritage in the UK and dont clearly explain how their outcomes achieve this. .page--in-your-area .page-header { Mutations in the FGFR3 gene cause achondroplasia. . Willemsen R, Oostra BA, Bassell GJ, Dictenberg J. They may have attention deficit disorder (ADD), which includes an impaired ability to maintain attention and difficulty focusing on specific tasks. Some affected people also develop abnormal front-to-back curvature of the spine (kyphosis) and back pain. rev2022.12.11.43106. i2c_arm bus initialization and device-tree overlay. display: block; 10.1016/j.brainresrev.2006.06.001. position: relative; Seattle (WA): University of Washington, Seattle; 1993-2022. I want to check if a value is in an accepted range. The inheritance pattern of schizoaffective disorder is unclear. 1998 Oct 12 [updated 2022 Jan 6]. Time complexity: O(n) Auxiliary Space: O(n) In fact it might be better to call min, max something like start, end. padding-left: 20px; 2005 margin-bottom: 40px; Seattle (WA): University of See our, URL of this page: https://medlineplus.gov/genetics/condition/fragile-x-syndrome/. In most cases, males experience more severe symptoms of the disorder than females. What are the different ways a genetic condition can be inherited? Epub 2011 Apr 3. Brain Res Rev. If a number is greater than another number >; If a number is smaller than another number <; If a number or text is equal to something =; The criteria_range1, criteria_range2, and so on, are the ranges where the function check for the conditions.. Examples might be simplified to improve reading and learning. Epub 2011 Oct 3. Mathematica cannot find square roots of some matrices? If the output column is of type json or jsonb, the JSON value is just reproduced exactly.. 10.1210/edrv.21.1.0387. You must have JavaScript enabled to use this form. We define the difference we want to make with our funding through a set of nine outcomes. Their sons receive a Y chromosome, which does not include the FMR1 gene. The premutation is also associated with an increased risk of disorders called fragile X-associated primary ovarian insufficiency (FXPOI) and fragile X-associated tremor/ataxia syndrome (FXTAS). When a principal makes a request to AWS, AWS gathers the request information into a request context. #block-contentfeedback { border-width: 1px; Calculate how many hours in a time range falls within a predefined Time Range, spanning midnight. Most males with fragile X syndrome have mild to moderate intellectual disability, while about one-third of affected females are intellectually disabled. Endocr Rev. Fragile X syndrome occurs in approximately 1 in 4,000 males and 1 in 8,000 females. Fragile X syndrome is inherited in an X-linked dominant pattern. In childhood, individuals with the condition usually develop a pronounced and permanent sway of the lower back (lordosis) and bowed legs. You can see declarations as "binding identifiers to values", and statements as "carrying out actions". color: #000; Last modified: 2022 11 7, by MDN contributors. Follow these easy steps to disable AdBlock, Follow these easy steps to disable AdBlock Plus, Follow these easy steps to disable uBlock Origin, Follow these easy steps to disable uBlock. Continuous Flow Centrifuge Market Size, Share, 2022 Movements By Key Findings, Covid-19 Impact Analysis, Progression Status, Revenue Expectation To 2028 Research Report - 1 min ago /* Cookie bar */ What is the prognosis of a genetic condition? The initial value of undefined is the primitive value undefined.. Laederich MB, Horton WA. font-size: 19px; MedlinePlus links to health information from the National Institutes of Health and other federal government agencies. What I am trying to accomplish is to create a condition between two cells in which a particular range of time is met. How do I check if an element is hidden in jQuery? /* Table caption */ a wider range of people will be involved in heritage, the funded organisation will be more resilient, the local area will be a better place to live, work or visit, heritage will be identified and better explained, people will have learnt about heritage, leading to change in ideas and actions, A wider range of people will be involved in heritage, The funded organisation will be more resilient, The local area will be a better place to live, work or visit, Heritage will be identified and better explained, People will have learned about heritage, leading to change in ideas and actions, what website content people are interested in. We urge you to read our privacy policy which gives you more control over your information and clearly explains how we use it. Fibroblast growth factor receptor 3 mutations in There is no obligation to name more than the mandatory outcome, particularly for projects within the 3,000 to 10,000 range, and we strongly encourage you not to claim more outcomes than you really think your project can deliver. Trustees of the National Heritage Memorial Fund. Unfortunately, the formula is still equaling zero on every test. If the hour is less than 20, output "Good day": The if/else statement executes a block of code if a specified condition is They are: We also expect all projects to demonstrate that they are building long-term environmental sustainability and inclusion into their plans. That's because I generally assume people know what they are asking for. , (? } } For example, if a project only delivered on the 'better condition outcome and the mandatory outcome, it would be much less likely to be supported than a project that met the mandatory outcome plus another priority outcome. In JavaScript, the operator is a little bit trickier and more powerful. Fragile X syndrome. } Whoops, you're right, I goofed. We reserve the right to make changes as required. skeletal dysplasias, Muenke craniosynostosis, and Crouzon syndrome with color: #000; solution. executed if a condition is true: The else statement specifies a block of code to be molecular genetics to neurobiology. .pager__item a.button { Achondroplasia. The if/else statement is a part of JavaScript's "Conditional" Statements, } Our role is to implement the National Disability Insurance Scheme (NDIS). Nat Rev Dis Primers. Jacquemont S, Hagerman RJ, Hagerman PJ, Leehey MA. Irreducible representations of a product of two groups. The number of outcomes you plan to achieve will depend on what you want to deliver. margin-right: 5px; } Eur J Med Genet. blockquote::before, blockquote::after { } /*-->*/. Vajo Z, Francomano CA, Wilkin DJ. The range header is used by HTTP clients to enable resuming of interrupted downloads, or split a download into multiple simultaneous streams. Cornish KM, Turk J, Wilding J, Sudhalter V, Munir F, Kooy F, Hagerman R. The National Disability Insurance Agency (NDIA) is an independent statutory agency. correlates of fragile X syndrome. Content available under a Creative Commons license. Annotation: Deconstructing the attention deficit in fragile X syndrome: a text-decoration: underline; Let's try this logic: Brilliant! Children with fragile X syndrome may also have anxiety and hyperactive behavior such as fidgeting or impulsive actions. MDN Web Docs . Not the answer you're looking for? Salcedo-Arellano MJ, Dufour B, McLennan Y, Martinez-Cerdeno V, Hagerman R. What does it mean if a disorder seems to run in my family? About one-third of individuals with fragile X syndrome have features of autism spectrum disorder that affect communication and social interaction. display: block; GeneReviews(R) [Internet]. How do I put three reasons together in a sentence? Google Docs New Feature: Table cell splitting Announcement Hi everyone, We're excited to announce a new feature launching soon on Google Docs: Table cell split const inRange = (num, num1, num2) => Math.min(num1, num2) <= num && Math.max(num1, num2) >= num; Could be like this if you want to make inRange inclusive and not depend on order of range numbers (num1, num2). Horton WA, Lunstrum GP. 10.1097/01.gim.0000182468.22666.dd. Call Centre Data - Assign Time Period Category to inbound call Start Time. morning" 14;370(9582):162-172. doi: 10.1016/S0140-6736(07)61090-3. 2000 Feb;21(1):23-39. doi: The condition occurs in 1 in 15,000 to 40,000 newborns. Neurobiol Dis. var letter = document.getElementById("myInput").value; W3Schools is optimized for learning and training. .breadcrumb > li + li::before { An expression that evaluates to true or false. Terracciano A, Chiurazzi P, Neri G. Fragile X syndrome. To use the sharing features on this page, please enable JavaScript. background-position: right bottom; , (? How can I know which radio button is selected via jQuery? We own and operate 500 peer-reviewed clinical, medical, life sciences, engineering, and management journals and hosts 3000 scholarly conferences per year in the fields of clinical, medical, pharmaceutical, life sciences, business, engineering and technology. display:none; Koukoui SD, Chaudhuri A. Neuroanatomical, molecular genetic, and behavioral However, in achondroplasia the problem is not in forming cartilage but in converting it to bone (a process called ossification), particularly in the long bones of the arms and legs. -moz-border-radius: 6px; -webkit-border-radius: 6px; The average height of an adult male with achondroplasia is 131 centimeters (4 feet, 4 inches), and the average height for adult females is 124 centimeters (4 feet, 1 inch). blockquote { http://www.ncbi.nlm.nih.gov/books/NBK1384/. list-style-type: disc; Men pass the premutation only to their daughters. 16 [updated 2019 Nov 21]. We need to understand the difference your project will make. No abstract available. border: 1px solid #dcdcdc; 2005 } We will communicate any changes as quickly as possible via this webpage. .form-control::placeholder { Fragile X syndrome and associated disorders: Clinical aspects and pathology. Sep;116(3):771-83. doi: 10.1542/peds.2005-1440. /* Publications TOC anchor link */ .breadcrumb { Another uncommon but serious complication of achondroplasia is hydrocephalus, which is a buildup of fluid in the brain in affected children that can lead to increased head size and related brain abnormalities. It is a viable option, nevertheless. I always judge a solution by how good it answers the question. . BCD tables only load in the browser with JavaScript enabled. false falsy null, NaN, 0, (""), undefined . font-size: 22px; U.S. Department of Health and Human Services. .eu-cookie-compliance-secondary-button { ), (truthy) , (:), (falsy) . 2017 Sep 29;3:17065. doi: 10.1038/nrdp.2017.65. /* Breadcrumb size increase */ otherwise a "Good evening": If the first