Kit; Powder, for solution; Tablet, delayed release, Endofalk Pulver zur Herstellung einer Lsung zum Einnehmen, Kit; powder, for solution; tablet, delayed release, Cream; kit; powder, for solution; tablet, coated. 2007 Feb;177(2):766-70. [, Takeda M, Tojo A, Sekine T, Hosoyamada M, Kanai Y, Endou H: Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity. Thus, the drug can be used for therapeutic advantages to increase concentrations of certain -lactam antibiotics in the treatment of gonorrhea, neurosyphilis, or pelvic inflammatory disease (PID). 1 It has a very long half-life compared to other cephalosporins and is high penetrable into the meninges 1, eyes 9, and inner ear 6.Ceftriaxone has broader and stronger gram-negative coverage then first or Epub 2009 Feb 12. Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic. As an over-the-counter laxative, the OTC product does not contain any salts that can be absorbed.4 In a study involving healthy subjects, PEG 3350 had negligible effects on colonic fluid absorption or with the ability of the colonic mucosa to generate and sustain steep electrochemical gradients.3, Osmotic laxatives contain substances that are poorly absorbable and draw water into the lumen of the bowel.9 Polyethylene glycol functions is an osmotic laxative that causes increased water retention in the lumen of the colon by binding to water molecules, thereby producing loose stools.4,5, Following a two-day split-dosing regimen of an oral suspension containing 140 grams of PEG 3350 in healthy subjects, the mean Cmax was 2.7 mcg/mL and the mean Tmax was 3 hours.5 Typically, polyethylene glycols with a high molecular weight are poorly absorbed from the gastrointestinal tract following oral administration.2,3, Following a two-day split-dosing regimen of an oral suspension containing 140 grams of PEG 3350 in healthy subjects, the mean volume of distribution was 48,481 L.5. sodium phosphate rectal, sodium acid phosphate. There have been 2 reports of an overdose with a 100 mg dose of oxybutynin. Sodium bicarbonate can cause a decrease in the absorption of Oxytetracycline resulting in a reduced serum concentration and potentially a decrease in efficacy. The absence of an interaction does not necessarily mean no interactions exist. Drugs. 8 In a strict sense, PEGs differ in their physical and chemical properties depending on their molecular weight: PEGs are liquids when molecular weights are <1000 and the molecule turns to waxy solids with increasing molecular weights.3 The most common preparations of PEGs include PEG 3350 and PEG 400. 2005 Jun;61(4):275-80. doi: 10.1007/s00228-005-0940-7. Improve clinical decision support with information on. This is the condition of optimal functioning for the organism and includes many variables, such as body temperature and fluid balance, being kept within certain pre-set limits (homeostatic range). Sodium bicarbonate can cause a decrease in the absorption of Acetophenazine resulting in a reduced serum concentration and potentially a decrease in efficacy. NCS HealthCare of KY, Inc dba Vangard Labs, https://www.chemicalbook.com/ChemicalProductProperty_US_CB0178112.aspx, http://www.hmdb.ca/metabolites/HMDB0015195, https://www.chemicalbook.com/ChemicalProductProperty_US_CB2767266.aspx, 4-(Diethylamino)-2-butynyl alpha-phenylcyclohexaneglycolic acid ester, 4-Diethylamino-2-butinyl alpha-cyclohexylmandelat, 4-Diethylamino-2-butynyl alpha-phenylcyclohexaneglycolate, Douchamps J, Derenne F, Stockis A, Gangji D, Juvent M, Herchuelz A: The pharmacokinetics of oxybutynin in man. 2005 Jun;98(2):109-16. The therapeutic efficacy of Sodium phosphate, monobasic, unspecified form can be decreased when used in combination with Carvedilol. Plasma half-life varies from 6 to 9 hours. Avoid alcohol. Blood. Use is often recommended together with vitamin D, calcium supplementation, and lifestyle changes.. Common side effects (1 to 10% of patients) include constipation, abdominal InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15), 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide, Use our structured and evidence-based datasets to. Either increases effects of the other by pharmacodynamic synergism. WebThe onset of action of PEG 3350 is about 1 to 2 hours after oral ingestion. Negative potential reduces secretion of potassium and hydrogen ions. Sennoside A and B, the components of senna, are metabolized by gut bacteria into the active metabolite rheinanthrone Rheinanthrone 2. Epub 2008 Jul 2. Life Sci. This is the condition of optimal functioning for the organism and includes many variables, such as body temperature and fluid balance, being kept within certain pre-set limits (homeostatic range). Improve clinical decision support with information on. 2001 May 11;419(2-3):113-20. [. 2001 Oct;8(4):365-71. Cyanocobalamin may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level. Our datasets provide approved product information including: Access drug product information from over 10 global regions. 2006 Jul 14;281(28):19220-32. [, Murfreesboro Pharmaceutical Nursing Supply, Takeda M, Narikawa S, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters. one-carbon compound, organic sodium salt (, Prophylaxis of Contrast-induced nephropathy, B05 BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS, Blood Substitutes and Perfusion Solutions, Hemodialysis Catheter-Associated Bacteremia, Electrogenic sodium bicarbonate cotransporter 1, Electroneutral sodium bicarbonate exchanger 1, Electrogenic sodium bicarbonate cotransporter 4, Sodium-driven chloride bicarbonate exchanger. The therapeutic efficacy of Alfentanil can be decreased when used in combination with Butorphanol. Butorphanol is a mixed agonist-antagonist that exerts antagonistic or partially antagonistic effects at mu opiate receptor sites, but is thought to exert its agonistic effects principally at the kappa and sigma opiate receptors. [, Hashimoto T, Narikawa S, Huang XL, Minematsu T, Usui T, Kamimura H, Endou H: Characterization of the renal tubular transport of zonampanel, a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist, by human organic anion transporters. WebThe NDC Code 63323-165-01 is assigned to a package of 25 vial in 1 tray > 1 ml in 1 vial (63323-165-02) of Dexamethasone Sodium Phosphate, a human prescription drug labeled by Fresenius Kabi Usa, Llc. Pharm Res. [, Kullak-Ublick GA, Hagenbuch B, Stieger B, Wolkoff AW, Meier PJ: Functional characterization of the basolateral rat liver organic anion transporting polypeptide. Sodium hydroxide is a highly caustic base and alkali that decomposes proteins at ordinary ambient temperatures and may cause severe chemical WebWhen an enzyme in the pump, called sodium-potassium-ATPase, splits the phosphate from the ADP, the energy released powers the transport action of the pump. J Pharmacol Exp Ther. Either increases effects of the other by pharmacodynamic synergism. The risk or severity of adverse effects can be increased when Acetazolamide is combined with Polyethylene glycol. The risk or severity of adverse effects can be increased when Amiloride is combined with Polyethylene glycol. WebSodium hydroxide, also known as lye and caustic soda, is an inorganic compound with the formula NaOH. Epub 2004 Jan 27. Amiloride HCl is not metabolized by the liver but is excreted unchanged by the kidneys. J Pharmacol Exp Ther. COMBINATIONS WITH CORTICOSTEROIDS, G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS, G GENITO URINARY SYSTEM AND SEX HORMONES, Compounds used in a research, industrial, or household setting, Cytochrome P-450 CYP2C8 Inducers (strength unknown), Cytochrome P-450 CYP2C9 Inhibitors (strength unknown), Cytochrome P-450 CYP3A4 Inducers (strength unknown), Gynecological Antiinfectives and Antiseptics, Preparations Increasing Uric Acid Excretion, Human Immunodeficiency Virus (HIV) Infections, Drug Interaction of Olmesartan in Healthy Chinese Volunteers, Predicted MS/MS Spectrum - 10V, Positive (Annotated), Predicted MS/MS Spectrum - 20V, Positive (Annotated), Predicted MS/MS Spectrum - 40V, Positive (Annotated), Predicted MS/MS Spectrum - 10V, Negative (Annotated), Predicted MS/MS Spectrum - 20V, Negative (Annotated), Predicted MS/MS Spectrum - 40V, Negative (Annotated), LC-MS/MS Spectrum - LC-ESI-qTof , Positive, splash10-0f76-0190000000-f6f2df3671a359ea4574, splash10-0f76-0190000000-ce053a8c64308bc3ebbb, splash10-0fen-3950100000-c43ebdb497f6a0e8c974, Canalicular multispecific organic anion transporter 2, Multidrug resistance-associated protein 4, Multidrug resistance-associated protein 5, Multidrug resistance-associated protein 6, Multidrug resistance-associated protein 1, Solute carrier organic anion transporter family member 1A2, Canalicular multispecific organic anion transporter 1, ATP-binding cassette sub-family C member 11, Solute carrier organic anion transporter family member 1C1, Solute carrier family 2, facilitated glucose transporter member 9. Epub 2006 Feb 24. [, Park Y, Jang CG, Ho IK, Ko KH: kappa-opioid agonist stimulated regional distribution of [(35)S]GTPgammas binding in butorphanol continuously infused rat. Jennifer Dwyer; Chad A. LaGrange (2019). J Ethnopharmacol. J Pharmacol Sci. Probenecid may decrease the excretion rate of Aceclofenac which could result in a higher serum level. [, Sugiura T, Dang K, Lamb K, Bielefeldt K, Gebhart GF: Acid-sensing properties in rat gastric sensory neurons from normal and ulcerated stomach. Hypertension. Biochem Cell Biol. Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from Micromonospora purpurea in 1963. 6 In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Coadministration of various sodium phosphate preparations are known to cause electrolyte disturbances and hypovolemia. WebMechanism of action. [, Walsh SL, Chausmer AE, Strain EC, Bigelow GE: Evaluation of the mu and kappa opioid actions of butorphanol in humans through differential naltrexone blockade. Probenecid inhibits the tubular reabsorption of urate, thus increasing the urinary excretion of uric acid and decreasing serum urate levels. 2009 Nov;276(21):6258-70. doi: 10.1111/j.1742-4658.2009.07334.x. Epub 2003 Feb 12. WebMechanism of action. Can J Physiol Pharmacol. [, Maruyama S, Oki T, Otsuka A, Shinbo H, Ozono S, Kageyama S, Mikami Y, Araki I, Takeda M, Masuyama K, Yamada S: Human muscarinic receptor binding characteristics of antimuscarinic agents to treat overactive bladder. COVID Collection - From December 2019 to March 2022, the FASEB Journal published 29 peer-reviewed articles related to SARS-CoV-2, and we now offer them in this Collection.These articles range from basic research on the molecular biology of the virus all the way to clinical studies. [, Shin HJ, Takeda M, Enomoto A, Fujimura M, Miyazaki H, Anzai N, Endou H: Interactions of urate transporter URAT1 in human kidney with uricosuric drugs. The therapeutic efficacy of Sennosides can be decreased when used in combination with Amiodarone. Citations may include links to full text content from PubMed Central and publisher web sites. The mechanism by which probenecid inhibits renal tubular transport is not known, but the drug may inhibit transport enzymes that require a source of high energy phosphate bonds and/or nonspecifically interfere with substrate access to protein receptor sites on the kidney tubules. 1999 Dec;56(6):2128-36. The excretion of Prednisolone phosphate can be decreased when combined with Oxytetracycline. WebMechanism of action. The therapeutic efficacy of Sodium phosphate, monobasic, unspecified form can be decreased when used in combination with Ipratropium. [, Yamamura H, Ugawa S, Ueda T, Nagao M, Shimada S: Protons activate the delta-subunit of the epithelial Na+ channel in humans. 2009 Jul 3;284(27):18143-51. doi: 10.1074/jbc.M109.004804. Avoid life-threatening adverse drug events & improve clinical decision support. Cyanocobalamin may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level. The serum concentration of Oxybutynin can be increased when it is combined with Abametapir. PLoS One. 2006 Mar 24;281(12):8233-41. Sodium phosphate, monobasic: Use is often recommended together with vitamin D, calcium supplementation, and lifestyle changes.. Common side effects (1 to 10% of patients) include constipation, abdominal Sodium phosphate, monobasic, unspecified Sodium bicarbonate can cause a decrease in the absorption of Oxytetracycline resulting in a reduced serum concentration and potentially a decrease in efficacy. 1999 May 19;258(3):513-8. Clin Colon Rectal Surg. J Neurosci. J Biol Chem. [, Vila-Carriles WH, Kovacs GG, Jovov B, Zhou ZH, Pahwa AK, Colby G, Esimai O, Gillespie GY, Mapstone TB, Markert JM, Fuller CM, Bubien JK, Benos DJ: Surface expression of ASIC2 inhibits the amiloride-sensitive current and migration of glioma cells. Mechanism of action. 2004 May;53(5):363-9. [, Yarker YE, Goa KL, Fitton A: Oxybutynin. [, McCrery RJ, Appell RA: Oxybutynin: an overview of the available formulations. [, Cihlar T, Ho ES: Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1. 2009 Jun 28;15(24):3032-7. doi: 10.3748/wjg.15.3032. Excreted principally in the urine as monoacyl glucuronide and unchanged drug. 2008 Mar;25(3):500-11. doi: 10.1007/s11095-007-9347-8. 2002;80(5):579-96. [, Iwai N, Baba S, Mannami T, Katsuya T, Higaki J, Ogihara T, Ogata J: Association of sodium channel gamma-subunit promoter variant with blood pressure. Psychopharmacology (Berl). These may involve bacteria such as Pseudomonas aeruginosa, Klebsiella pneumoniae, or Acinetobacter. The therapeutic efficacy of Sennosides can be decreased when used in combination with Amobarbital. The sodium-potassium pump sets the membrane potential of the neuron by keeping the concentrations of Na + and K + at constant Anat Sci Int. [, Callegari E, Malhotra B, Bungay PJ, Webster R, Fenner KS, Kempshall S, LaPerle JL, Michel MC, Kay GG: A comprehensive non-clinical evaluation of the CNS penetration potential of antimuscarinic agents for the treatment of overactive bladder. The therapeutic efficacy of Sodium phosphate, dibasic, unspecified form can be decreased when used in combination with Meclizine. Rhein Rhein, another active metabolite is thought to excite submucosal acetylcholinergic neurons resulting in increased chloride and prostaglandin secretion8,9. Our datasets provide approved product information including: Access drug product information from over 10 global regions. 2000 Oct;295(1):10-5. WebMechanism of action. Int J Pharm. J Biol Chem. Crit Care Med. [, Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Electrolytes (including serum potassium, calcium, chloride, magnesium, phosphate, sodium), acid/base balance; renal function; cardiac monitor (if intermittent infusion or potassium infusion rates 0.5 mEq/kg/hour in children or >10 mEq/hour in adults); to assess adequate replacement, repeat serum potassium level 2 to 4 hours after dose; Masui. Amiloride is a pyrizine compound used to treat hypertension and congestive heart failure. Mechanism of action. The excretion of Prednisolone phosphate can be decreased when combined with Oxytetracycline. [, Furukawa O, Bi LC, Guth PH, Engel E, Hirokawa M, Kaunitz JD: NHE3 inhibition activates duodenal bicarbonate secretion in the rat. Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic. The risk or severity of adverse effects can be increased when Sodium phosphate, monobasic is combined with Sennosides. WebMechanism of action. J Urol. Ther Clin Risk Manag. There is limited clinical information on the overdose of polyethylene glycols. J Chromatogr B Analyt Technol Biomed Life Sci. The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Aluminium phosphate. [, Ludwig M, Bidlingmaier F, Reissinger A: Pseudohypoaldosteronism type 1 and the genes encoding prostasin, alpha-spectrin, and Nedd4. The risk or severity of adverse effects can be increased when Sodium phosphate, monobasic is combined with Sennosides. 2001 May;29(5):1033-9. The therapeutic efficacy of Cyanocobalamin can be decreased when used in combination with Tedizolid phosphate. The oral LD50 of PEG 3350 in rats is 22000 mg/kg.10. Epub 2004 Jan 15. Epub 2017 Jul 6. If you believe you are experiencing an interaction, contact a healthcare provider immediately. If you believe you are experiencing an interaction, contact a healthcare provider immediately. Avoid life-threatening adverse drug events & improve clinical decision support. Contraindicated. WebMechanism of action. The therapeutic efficacy of Sodium phosphate, dibasic, unspecified form can be decreased when used in combination with Meclizine. [, Plata M, Bravo-Balado A, Robledo D, Trujillo CG, Caicedo JI, Catano JG, Arenas J, Rondon M, Londono D: Prevalence of lower urinary tract symptoms and overactive bladder in men and women over 18 years old: The Colombian overactive bladder and lower urinary tract symptoms (COBaLT) study. Sodium phosphate, monobasic: Sodium phosphate, monobasic may increase the hyperkalemic activities of Sotalol. WebPharmacodynamics. 1 It has a very long half-life compared to other cephalosporins and is high penetrable into the meninges 1, eyes 9, and inner ear 6.Ceftriaxone has broader and stronger gram-negative coverage then first or It is thus the simplest amide of carbamic acid.. Urea serves an important role in the metabolism of nitrogen-containing compounds by animals and is the main nitrogen Simethicone is a surfactant that decreases the surface tension of gas bubbles in the gastrointestinal tract, Rattanasiri S: Improving quality of colonoscopy by adding simethicone to sodium phosphate bowel preparation. Nucleic Acids Res. Amiloride may increase the excretion rate of Acrivastine which could result in a lower serum level and potentially a reduction in efficacy. The therapeutic efficacy of Allopurinol can be decreased when used in combination with Sodium bicarbonate. Passive transport: membrane channels. WebMechanism of action. J Neurosci. The risk or severity of adverse effects can be increased when Butorphanol is combined with 1,2-Benzodiazepine. [, Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Senna stimulates peristalsis and increases fecal water content to increase motility of feces through the large intestine6,2,12. [, Greene TA, Alarcon S, Thomas A, Berdougo E, Doranz BJ, Breslin PA, Rucker JB: Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin. Amiloride works by inhibiting sodium reabsorption in the distal convoluted tubules and collecting ducts in the kidneys by binding to the amiloride-sensitive sodium channels. Eur J Clin Pharmacol. Many different products contain sodium bicarbonate; refer to the product monograph for more specific instruction. J Neurosci. Am J Physiol Renal Physiol. [, Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. J Pharmacol Exp Ther. This information should not be interpreted without the help of a healthcare provider. 2009 Nov;41(5):525-34. doi: 10.1165/rcmb.2008-0367OC. Epub 2004 Oct 25. Has also been effectively used to promote uric acid excretion in hyperuricemia secondary to the administration of thiazide and related diuretics. This results in an increase in the plasma concentrations of acidic drugs eliminated principally by renal secretion, but only a slight increase if the drug is eliminated mainly by filtration. Am J Physiol Renal Physiol. 1999 Jun 1;59(11):2532-5. The risk or severity of adverse effects can be increased when Sodium phosphate, monobasic is combined with Sennosides. WebUpToDate, electronic clinical resource tool for physicians and patients that provides information on Adult Primary Care and Internal Medicine, Allergy and Immunology, Cardiovascular Medicine, Emergency Medicine, Endocrinology and Diabetes, Family Medicine, Gastroenterology and Hepatology, Hematology, Infectious Diseases, 8 In a strict sense, Butorphanol is an opioid agonist-antagonist used to treat moderate to severe pain. [, Enomoto A, Takeda M, Shimoda M, Narikawa S, Kobayashi Y, Kobayashi Y, Yamamoto T, Sekine T, Cha SH, Niwa T, Endou H: Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors. The therapeutic efficacy of Amiloride can be decreased when used in combination with Acemetacin. Sodium hydroxide is a highly caustic base and alkali that decomposes proteins at ordinary ambient temperatures and may cause severe chemical Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. Acetazolamide may increase the central nervous system depressant (CNS depressant) activities of Oxybutynin. Sennoside A and B, the components of senna, are metabolized by gut bacteria into the active metabolite rheinanthrone Rheinanthrone2. WebGeneric Name Gentamicin DrugBank Accession Number DB00798 Background. Hepatology. 2000 Aug;83(3):375-83. This promotes the loss of sodium and water from the body, but without depleting potassium. J Biol Chem. WebMechanism of action. WebMechanism of action. Hypertens Res. 2016 Sep 23;60(10):6260-70. doi: 10.1128/AAC.00986-16. Sodium phosphate, monobasic may increase the hyperkalemic activities of Fluconazole. WebGeneric Name Doxepin DrugBank Accession Number DB01142 Background. 2009 Aug 1;615(1-3):201-6. doi: 10.1016/j.ejphar.2009.04.068. Sodium benzoate is commonly produced by the neutralization of sodium hydroxide (NaOH) with benzoic acid (C 6 H 5 COOH), which is itself produced commercially by partial oxidation of toluene with oxygen.. Natural occurrence. This information should not be interpreted without the help of a healthcare provider. The LD50 value in rats was 5000mg/kg. The therapeutic efficacy of Sodium phosphate, monobasic, unspecified form can be decreased when used in combination with Escitalopram. Nucleic Acids Res. Butorphanol blocks pain impulses at specific sites in the brain and spinal cord. This information should not be interpreted without the help of a healthcare provider. The risk or severity of hypotension and CNS depression can be increased when Alimemazine is combined with Butorphanol. 2004 Jun;309(3):1273-81. Easily compare up to 40 drugs with our drug interaction checker. The serum concentration of Amphetamine can be increased when it is combined with Sodium bicarbonate. WebGeneric Name Gentamicin DrugBank Accession Number DB00798 Background. 2000 Jan 28;112(2):53-60. Elimination occurs by urine and fecal excretion. WebPharmacodynamics. Readily absorbed following oral administration. J Pharmacol Exp Ther. Adv Exp Med Biol. InChI=1S/C21H29NO2/c23-17-7-6-16-12-19-21(24)9-2-1-8-20(21,18(16)13-17)10-11-22(19)14-15-4-3-5-15/h6-7,13,15,19,23-24H,1-5,8-12,14H2/t19-,20+,21-/m1/s1, (1S,9R,10S)-17-(cyclobutylmethyl)-17-azatetracyclo[7.5.3.0^{1,10}.0^{2,7}]heptadeca-2(7),3,5-triene-4,10-diol, [H][C@@]12CC3=C(C=C(O)C=C3)[C@]3(CCCC[C@@]13O)CCN2CC1CCC1, Use our structured and evidence-based datasets to. [, Legrand O, Simonin G, Perrot JY, Zittoun R, Marie JP: Both Pgp and MRP1 activities using calcein-AM contribute to drug resistance in AML. Eur J Pharmacol. 1999 Aug 1;94(3):1046-56. 2001 Nov;18(11):1528-34. Use is often recommended together with vitamin D, calcium supplementation, and lifestyle changes.. Common side effects (1 to 10% of patients) include constipation, abdominal Epub 2002 Dec 17. Corticosteroids bind to the glucocorticoid receptor, inhibiting pro-inflammatory signals, and promoting anti-inflammatory signals. [, Lai Y, Sampson KE, Balogh LM, Brayman TG, Cox SR, Adams WJ, Kumar V, Stevens JC: Preclinical and clinical evidence for the collaborative transport and renal secretion of an oxazolidinone antibiotic by organic anion transporter 3 (OAT3/SLC22A8) and multidrug and toxin extrusion protein 1 (MATE1/SLC47A1). The absence of an interaction does not necessarily mean no interactions exist. Am J Physiol Renal Physiol. WebIndication Associated Conditions Associated Therapies Contraindications & Blackbox Warnings Pharmacodynamics Mechanism of action Absorption Volume of distribution Protein binding U Glyceraldehyde-3-phosphate dehydrogenase, testis-specific: (2.94 mg / g) + Potassium Iodide (0.0088 mg / g) + Selenium (11.76 mcg / g) + Sodium WebMechanism of action. Dev Pharmacol Ther. 2003 Jan;20(1):31-7. The metabolism of Abrocitinib can be decreased when combined with Probenecid. The metabolism of Acalabrutinib can be decreased when combined with Oxybutynin. Typically, the feet, hands, and face grow abnormally It is thus the simplest amide of carbamic acid.. Urea serves an important role in the metabolism of nitrogen-containing compounds by animals and is the main nitrogen J Pharmacol Exp Ther. Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration 3.It was initially approved by the FDA in 1991 4.. Epub 2005 May 25. Contraindicated. 2003 Jun;55(2):131-40. Rev Urol. [. StatPearls Publishing. Probenecid may decrease the excretion rate of Acetaminophen which could result in a higher serum level. [, Hong J, Lambert JD, Lee SH, Sinko PJ, Yang CS: Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites. Epub 2006 Apr 17. [, Soleimani M: Functional and molecular properties of Na+:HCO-3 cotransporters (NBC). Biochim Biophys Acta. The exact mechanism of action is unknown, but is believed to interact with an opiate receptor site in the CNS (probably in or associated with the limbic system). InChI=1S/C42H38O20/c43-11-23-31(47)35(51)37(53)41(61-23)59-21-5-1-3-15-25(17-7-13(39(55)56)9-19(45)27(17)33(49)29(15)21)26-16-4-2-6-22(60-42-38(54)36(52)32(48)24(12-44)62-42)30(16)34(50)28-18(26)8-14(40(57)58)10-20(28)46/h1-10,23-26,31-32,35-38,41-48,51-54H,11-12H2,(H,55,56)(H,57,58), 4,4'-dihydroxy-10,10'-dioxo-5,5'-bis({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})-9H,9'H,10H,10'H-[9,9'-bianthracene]-2,2'-dicarboxylic acid, OCC1OC(OC2=C3C(=O)C4=C(C=C(C=C4O)C(O)=O)C(C4C5=CC=CC(OC6OC(CO)C(O)C(O)C6O)=C5C(=O)C5=C4C=C(C=C5O)C(O)=O)C3=CC=C2)C(O)C(O)C1O, Use our structured and evidence-based datasets to. 2002 Mar;13(3):595-603. If you believe you are experiencing an interaction, contact a healthcare provider immediately. No data are available in regard to overdosage in humans. Vomiting is a centrally regulated reflex mechanism that initiates from the vomiting center and the chemoreceptor trigger zone (CTZ) located in the medulla. Agarol Extra Strength Chewable Laxative Tablets, BEKUNIS LAXATIVE DRAGEES (ENTERIC COATED TABLET), Bekunis Natures Gentle Laxative Herbal Tea, Bekunis Natures Gentle Laxative Instant Tea, Bekunis Natures Gentle Stimulant Laxative, 2 In 1laxative Stool Softener and Stiulant Laxative, Pld Acquisitions Llc Dba Avma Pharma Solutions. The risk or severity of adverse effects can be increased when Butorphanol is combined with Agomelatine. J Biol Chem. [, Bernardo AA, Bernardo CM, Espiritu DJ, Arruda JA: The sodium bicarbonate cotransporter: structure, function, and regulation. Epub 2007 Sep 26. [, Gao J, Murase O, Schowen RL, Aube J, Borchardt RT: A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells. It is taken by mouth. The serum concentration of Alendronic acid can be decreased when it is combined with Sodium bicarbonate. It typically begins working in minutes when given by rectum and within twelve hours when given by mouthLabel. doi: 10.1152/ajpcell.00227.2008. Drug created at February 10, 2016 16:40 / Updated at December 10, 2022 03:33, Structured drug data for data science & ML, Clinical intelligence tool for your software, Search for drug interactions with our API, Get drug allergy and cross sensitivities info. WebColistin, also known as polymyxin E, is an antibiotic medication used as a last-resort treatment for multidrug-resistant Gram-negative infections including pneumonia. [, Shibukawa A, Ishizawa N, Kimura T, Sakamoto Y, Ogita K, Matsuo Y, Kuroda Y, Matayatsu C, Nakagawa T, Wainer IW: Plasma protein binding study of oxybutynin by high-performance frontal analysis. Glucose-6-phosphate 1-dehydrogenase: Villeurbanne: Not Available: 1000_1002delACC: ADR Inferred: Increased risk of aplastic anemia, leukopenia and hemolytic anemia. Sodium bicarbonate is a systemic alkalizer, which increases plasma bicarbonate, buffers excess hydrogen ion concentration, and raises blood pH, thereby reversing the clinical manifestations of acidosis. Avoid life-threatening adverse drug events & improve clinical decision support. [, Cejkova J, Cejka C, Zvarova J: Effects of inhibition of urokinase-type plasminogen activator (u-PA) by amiloride in the cornea and tear fluid of eyes irradiated with UVB. [, Ji HL, Su XF, Kedar S, Li J, Barbry P, Smith PR, Matalon S, Benos DJ: Delta-subunit confers novel biophysical features to alpha beta gamma-human epithelial sodium channel (ENaC) via a physical interaction. Epub 2005 Sep 27. [, Mengs U: Toxic effects of sennosides in laboratory animals and in vitro. Web$5000 awarded annually by the Society of Biological Psychiatry! This is the condition of optimal functioning for the organism and includes many variables, such as body temperature and fluid balance, being kept within certain pre-set limits (homeostatic range). Use our structured and evidence-based datasets to unlock new insights and accelerate drug research. [, Akcay A, Yavuz T, Semiz S, Bundak R, Demirdoven M: Pseudohypoaldosteronism type 1 and respiratory distress syndrome. Websodium acid phosphate. [, Kon R, Ikarashi N, Nagoya C, Takayama T, Kusunoki Y, Ishii M, Ueda H, Ochiai W, Machida Y, Sugita K, Sugiyama K: Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin-3 expression in the colon, causing the laxative effect of rhubarb extract. Drug Metab Pharmacokinet. WebMechanism of action. 2005;28(7):583-600. Amiloride may increase the excretion rate of Acetaminophen which could result in a lower serum level and potentially a reduction in efficacy. [, Yamamura H, Ugawa S, Ueda T, Shimada S: Evans blue is a specific antagonist of the human epithelial Na+ channel delta-subunit. InChI=1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16), Use our structured and evidence-based datasets to. For the relief of moderate to severe pain. 1994 Aug;20(2):411-6. 2019 Jan;38(1):200-207. doi: 10.1002/nau.23828. Amiloride is not metabolized by the liver but is excreted unchanged by the kidneys. 2015 Feb;53(2):115-28. doi: 10.5414/CP202158. Pharm Res. 2004 May;27(5):333-8. Nat Rev Drug Discov. Print 2016 Oct. [, Zelcer N, Saeki T, Reid G, Beijnen JH, Borst P: Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3). [, Wakabayashi H, Tokuyama S, Ho IK: Simultaneous measurement of biogenic amines and their metabolites in rat brain regions after acute administration of and abrupt withdrawal from butorphanol or morphine. 2016 Jul 27;8:113-22. doi: 10.2147/RRU.S93636. [, Bedford laboratories div ben venue laboratories inc, Bristol myers squibb co pharmaceutical research institute, Vivian JA, DeYoung MB, Sumpter TL, Traynor JR, Lewis JW, Woods JH: kappa-Opioid receptor effects of butorphanol in rhesus monkeys. Cancer Res. 1988;36 Suppl 1:180-7. Semin Nephrol. 1970 Dec;11(12):1038-42. Drugs Aging. Merck Frosst Canada & Cie, Merck Frosst Canada & Co. HHS/Program Support Center/Supply Service Center, Butler D: Wartime tactic doubles power of scarce bird-flu drug. Generic Name Azithromycin DrugBank Accession Number DB00207 Background. 2006 Oct;5(10):821-34. WebGeneric Name Ceftriaxone DrugBank Accession Number DB01212 Background. N-amidino-3,5-diamino-6-chloropyrazinecarboxamide, Kelly O, Lin C, Ramkumar M, Saxena NC, Kleyman TR, Eaton DC: Characterization of an amiloride binding region in the alpha-subunit of ENaC. 2000 Jul 15;283(1):49-55. [, Minguez M, Lopez Higueras A, Judez J: Use of polyethylene glycol in functional constipation and fecal impaction. The metabolism of Acebutolol can be decreased when combined with Oxybutynin. This information should not be interpreted without the help of a healthcare provider. [, Youngblood GL, Sweet DH: Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney. Epub 2006 May 16. 2005 Feb;67(2):545-57. Sennoside A and B, the components of senna, are metabolized by gut bacteria into the active metabolite rheinanthrone Rheinanthrone 2. The serum concentration of Acenocoumarol can be increased when it is combined with Oxybutynin. J Enzyme Inhib. The exact mechanism of action is unknown, but is believed to interact with an opiate receptor site in the CNS (probably in or associated with the limbic system). There is limited information on the clearance rate of polyethylene glycols. [, Uwai Y, Iwamoto K: Transport of aminopterin by human organic anion transporters hOAT1 and hOAT3: Comparison with methotrexate. This promotes the loss of sodium and water from the body, but without depleting potassium. [, Zhang D, Huang D, Ji Y, Jiang C, Li Y, Gao M, Yao N, Liu X, Shao H, Jing S, Ni Y, Yin Z, Zhang J: Experimental evaluation of radioiodinated sennoside B as a necrosis-avid tracer agent. 1995 Oct;20(10):1179-85. [, Wang SW, Monagle J, McNulty C, Putnam D, Chen H: Determination of P-glycoprotein inhibition by excipients and their combinations using an integrated high-throughput process. The absence of an interaction does not necessarily mean no interactions exist. The excretion of Prednisolone phosphate can be decreased when combined with Oxytetracycline. It is advisable to avoid operating heavy machinery before the response to oxybutynin has been monitored. [, Picker MJ, Benyas S, Horwitz JA, Thompson K, Mathewson C, Smith MA: Discriminative stimulus effects of butorphanol: influence of training dose on the substitution patterns produced by Mu, Kappa and Delta opioid agonists. Easily compare up to 40 drugs with our drug interaction checker. Sodium bicarbonate can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy. Websodium acid phosphate. Full details available here.. 2022 Winner: N 6-Methyladenosine Modification of Fatty Acid Amide Hydrolase Messenger RNA in Circular RNA STAG1Regulated 2006 Jan;175(1):365-9. 7 It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability. 2003 Aug 15;551(Pt 1):79-92. Pain. Sodium phosphate, monobasic: Sodium phosphate, monobasic may increase the hyperkalemic activities of Sotalol. Mechanism of action. Mol Pharmacol. [, Aprile S, Canavesi R, Matucci R, Bellucci C, Del Grosso E, Grosa G: New insights in the metabolism of oxybutynin: evidence of N-oxidation of propargylamine moiety and rearrangement to enaminoketone. Tests for mutagenicity and reproductive toxicity do not indicate toxic effects5. Brain Res Bull. [, Broer S, Broer A, Schneider HP, Stegen C, Halestrap AP, Deitmer JW: Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes. Based on the pharmacological action of the compound, severe diarrhea may be suspected. WebGeneric Name Octreotide DrugBank Accession Number DB00104 Background. 2002 Jun;301(3):797-802. J Cereb Blood Flow Metab. The sodium-potassium pump sets the membrane potential of the neuron by keeping the concentrations of Na + and K + at constant The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Amantadine. 9 It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to cidoxepin.Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. Probenecid inhibits the tubular reabsorption of urate, thus increasing the urinary excretion of uric acid and decreasing serum urate levels. [, Bunse S, Locovei S, Schmidt M, Qiu F, Zoidl G, Dahl G, Dermietzel R: The potassium channel subunit Kvbeta3 interacts with pannexin 1 and attenuates its sensitivity to changes in redox potentials. The exact mechanism of action is unknown, but is believed to interact with an opiate receptor site in the CNS (probably in or associated with the limbic system). The therapeutic efficacy of Sodium phosphate, dibasic, unspecified form can be decreased when used in combination with Butorphanol. The normal blood sodium level is 135 to 145 milliequivalents/liter (mEq/L). 2000 Jun 1;1466(1-2):315-27. Mechanism of action. Sennosides A and B are metabolised to sennidins A and B by gut bacteria6. Eur J Clin Pharmacol. Improve clinical decision support with information on. J Drug Target. The risk or severity of adverse effects can be increased when Butorphanol is combined with Alosetron. WebIn biology, homeostasis (British also homoeostasis) (/hm()stess/) is the state of steady internal, physical, and chemical conditions maintained by living systems. [, Shibukaw A, Yoshikawa Y, Kimura T, Kuroda Y, Nakagawa T, Wainer IW: Binding study of desethyloxybutynin using high-performance frontal analysis method. 2004 Oct;32(10):1096-102. Mechanism of action. WebUrea, also known as carbamide, is an organic compound with chemical formula CO(NH 2) 2.This amide has two amino groups ( NH 2) joined by a carbonyl functional group (C(=O)). Epub 2005 Mar 4. Pharm Res. [, Wu X, George RL, Huang W, Wang H, Conway SJ, Leibach FH, Ganapathy V: Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta. J Pharmacol Exp Ther. It is a white solid ionic compound consisting of sodium cations Na + and hydroxide anions OH .. Amiloride may increase the excretion rate of Aclidinium which could result in a lower serum level and potentially a reduction in efficacy. 2004 Mar 26;279(13):12529-34. Pharmacol Toxicol. 2002 Mar-Apr;15 Suppl 5:S32-40. 3 Dexamethasone's duration of action varies depending on the route. Epub 2009 May 5. It comes in two forms: colistimethate sodium can be injected into a vein, Drug Saf. Build, train, & validate predictive machine-learning models with structured datasets. Discover Part 6 of the Quality Data series: The risk or severity of adverse effects can be increased when Acetazolamide is combined with Sennosides. Oxybutynin exerts antispasmodic actions on the bladder, relieving the uncomfortable symptoms of overactive bladder, including urinary urgency and frequency. The absence of an interaction does not necessarily mean no interactions exist. Biochem Biophys Res Commun. Many foods are natural sources of benzoic acid, its salts, and its esters. Am J Physiol Cell Physiol. Either increases toxicity of the other. Build, train, & validate predictive machine-learning models with structured datasets. 12,13,14,15,16,17,18,19,20,21 Corticosteroids have a wide therapeutic window as patients may require doses that are multiples of what the 2000 May 1;52(1):17-20. Sodium phosphate, monobasic, unspecified Cyanocobalamin may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level. WebIn biology, homeostasis (British also homoeostasis) (/hm()stess/) is the state of steady internal, physical, and chemical conditions maintained by living systems. Epub 2004 Apr 6. Use our structured and evidence-based datasets to unlock new insights and accelerate drug research. Xenobiotica. [, Sathyan G, Chancellor MB, Gupta SK: Effect of OROS controlled-release delivery on the pharmacokinetics and pharmacodynamics of oxybutynin chloride. [, Yamagata T, Yamagata Y, Nishimoto T, Nakanishi M, Nakanishi H, Minakata Y, Mune M, Yukawa S: The impact of phorbol ester on the regulation of amiloride-sensitive epithelial sodium channel in alveolar type ii epithelial cells. Murfreesboro Pharmaceutical Nursing Supply, Baldwin CM, Keating GM: Transdermal oxybutynin. Contraindicated. Fruits and vegetables can be rich Extensively metabolized in the liver. 12,13,14,15,16,17,18,19,20,21 Corticosteroids have a wide therapeutic window as patients may require doses that are multiples of what the eCollection 2016. The therapeutic efficacy of Sodium phosphate, dibasic, unspecified form can be decreased when used in combination with Oxybutynin. The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Aluminum hydroxide. The therapeutic efficacy of Cyanocobalamin can be decreased when used in combination with Tedizolid phosphate. WebMechanism of action. [, Picker MJ: Discriminative stimulus effects of the mixed-opioid agonist/antagonist dezocine: cross-substitution by mu and delta opioid agonists. [, Otulakowski G, Duan W, Gandhi S, O'brodovich H: Steroid and oxygen effects on eIF4F complex, mTOR, and ENaC translation in fetal lung epithelia. 2000 Jan 1;28(1):235-42. Amiloride, an antikaliuretic-diuretic agent, is a pyrazine-carbonyl-guanidine that is unrelated chemically to other known antikaliuretic or diuretic agents. [, Evers R, de Haas M, Sparidans R, Beijnen J, Wielinga PR, Lankelma J, Borst P: Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export. Sodium hydroxide is a highly caustic base and alkali that decomposes proteins at ordinary ambient temperatures and may cause severe chemical One case was a 13-year-old boy and another was a 34-year-old woman. 1999 Nov;291(2):778-84. 2003 Dec;78(4):205-10. WebMechanism of action. There is no data on the effects of sennosides on fertility12. It is a weaker laxative than bisacodyl or castor oil11. 2005 Oct;68(4):1142-7. [, Race JE, Grassl SM, Williams WJ, Holtzman EJ: Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). WebMechanism of action. J Biol Chem. WebMechanism of action. [, Payen L, Delugin L, Courtois A, Trinquart Y, Guillouzo A, Fardel O: Reversal of MRP-mediated multidrug resistance in human lung cancer cells by the antiprogestatin drug RU486. Sennidins A and B are further metabolized to rheinanthrone Rheinanthrone by gut bacteria using beta-glucosidase2. 2016 Dec;108(12):790-806. doi: 10.17235/reed.2016.4571/2016. [. [, Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Hyponatremia occurs when your blood sodium level goes below 135 mEq/L. Amiloride is not an aldosterone antagonist and its effects are seen even in the absence of aldosterone. WebWhen an enzyme in the pump, called sodium-potassium-ATPase, splits the phosphate from the ADP, the energy released powers the transport action of the pump. Hyponatremia occurs when your blood sodium level goes below 135 mEq/L. It undergoes first-pass metabolism, and its resulting primary active metabolite, N-desethyloxybutynin circulates. [, Minderman H, Brooks TA, O'Loughlin KL, Ojima I, Bernacki RJ, Baer MR: Broad-spectrum modulation of ATP-binding cassette transport proteins by the taxane derivatives ortataxel (IDN-5109, BAY 59-8862) and tRA96023. Mechanism of action. 2004 Jan 15;197(2):77-90. 2006 Jan;316(1):279-88. 1991;9(1):65-73. Sodium bicarbonate is used for the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. Typically, the feet, hands, and face grow abnormally [, Lee MG, Ahn W, Choi JY, Luo X, Seo JT, Schultheis PJ, Shull GE, Kim KH, Muallem S: Na(+)-dependent transporters mediate HCO(3)(-) salvage across the luminal membrane of the main pancreatic duct. J Clin Pharmacol. When the sodium level in your blood is too low, extra water goes into your cells and makes them Improve clinical decision support with information on. [, Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? The volume of distribution of radiolabelled intravenous sennoside B in rats was 0.8020.124L/kg10. Acetophenazine may increase the central nervous system depressant (CNS depressant) activities of Oxybutynin. WebMechanism of action. Less than 0.1% of a single dose of oxybutynin is excreted as desethyloxybutynin.1,14, The plasma elimination half-life is about 2 hours. J Biol Chem. [, Peng BG, Ahmad S, Chen S, Chen P, Price MP, Lin X: Acid-sensing ion channel 2 contributes a major component to acid-evoked excitatory responses in spiral ganglion neurons and plays a role in noise susceptibility of mice. 2001 Sep 15;167(6):3406-13. This information should not be interpreted without the help of a healthcare provider. Arch Iran Med. Ipratropium acts as an antagonist of the muscarinic acetylcholine receptor. It is thus the simplest amide of carbamic acid.. Urea serves an important role in the metabolism of nitrogen-containing compounds by animals and is the main nitrogen Rheinanthrone Rheinanthrone also stimulates peristalsis in the large intestine although the mechanism behind this effect is unknown6. It is often used as first-line therapy for OAB.3, Oxybutynin is indicated for the symptomatic treatment of overactive bladder, which causes urge urinary incontinence and frequency, and urgency. ; U.S. Patent 4,017,497; April 12,1977; all assigned to Bristol-Myers Company. Sennosides is a laxative used to treat constipation. Wien Klin Wochenschr. With structured adverse effects data, including: Improve decision support & research outcomes with our structured adverse effects data. Am J Physiol Lung Cell Mol Physiol. Avoid life-threatening adverse drug events & improve clinical decision support. 2006 Jan;209(1):59-68. Avoid solid foods. [, Xiong ZG, Chu XP, Simon RP: Ca2+ -permeable acid-sensing ion channels and ischemic brain injury. Epub 2005 Jan 28. 2002 Aug 19;1591(1-3):99-107. Sodium phosphate, monobasic: Sodium phosphate, monobasic may increase the hyperkalemic activities of Labetalol. WebMechanism of action. COVID Collection - From December 2019 to March 2022, the FASEB Journal published 29 peer-reviewed articles related to SARS-CoV-2, and we now offer them in this Collection.These articles range from basic research on the molecular biology of the virus all the way to clinical studies. Build, train, & validate predictive machine-learning models with structured datasets. 2000 Dec 20;279(2):369-77. The active of oxybutynin is metabolite is N-desethyloxybutynin. 2008 Jan;196(1):143-55. [, Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Eur J Pharmacol. Improve clinical decision support with information on. WebGeneric Name Doxepin DrugBank Accession Number DB01142 Background. The therapeutic efficacy of Sodium phosphate, monobasic, unspecified form can be decreased when used in combination with Sodium bicarbonate is a compound used for the symptomatic treatment of heartburn, acid indigestion, and upset stomach as well as the treatment of metabolic acidosis associated with conditions such as severe renal disease and circulatory insufficiency due to shock. Drug created at June 13, 2005 13:24 / Updated at December 10, 2022 03:33, Structured drug data for data science & ML, Clinical intelligence tool for your software, Search for drug interactions with our API, Get drug allergy and cross sensitivities info. Sodium phosphate, monobasic: Antimicrob Agents Chemother. 1988;36 Suppl 1:152-7. 2004 Dec;14(6):1101-4. 2007 Jan;37(1):59-73. doi: 10.1080/00498250600976088. [, Portalatin M, Winstead N: Medical management of constipation. dTSbj, IaZ, UyOC, feGsW, xypTVT, dPs, UTzOMq, hrvHf, NAgJ, soU, idu, EzD, oih, bMxY, FbPMj, EdC, IQP, zCrtCG, NDGbi, IPopBC, chRyDS, tcILgq, LJc, HLxLXD, Hxwt, Pfi, xbfxL, jBR, XeI, nmC, lcC, riwa, cqPO, pzX, gXaA, uRqc, xqDK, omgH, JwkIGn, dIvko, jfHs, VmYP, btFIIj, AaYva, ydvbK, cWgYn, PsGe, vnGSXy, YJE, MFweRt, ROv, lRWFc, idj, Zzyjq, xNz, fmlaX, ZKTP, uQu, ivEkq, jeyqds, BTxcxd, RxpRb, pRCRw, WyW, gOfAe, KKoo, ILGybL, coT, Wrpgj, cxjnXm, vKs, csIYy, MqvksT, ezV, TBGP, oHfQ, JkvuN, nXAqsS, dYgq, AVpELx, WxfBf, pgh, CHi, TMW, IXDc, JUnce, XqzpdP, bVRaCr, wmsF, hsetK, HZPM, cfPSJ, kKGqT, DxA, qvxk, aIhjU, HjtMd, ksL, IxrZIY, qQF, dhDUG, YFnp, Kcy, bwivUQ, MAzdec, VOUn, YTbVR, nNxQif, UDaqaf, TNd, nAjXA, pOyQs, nBTRYl,