The safety profile of hydroxyurea (HU) in patients with sickle-cell disease (SCD) is relatively well known. The condition affects the ability of a child to attend school regularly, learn and remember, focus or concentrate on school work, etc. Chest pain should be treated as an acute chest syndrome and not simply as a vaso-occlusive crisis. NHGRI project creates new educational materials for sickle cell disease community Sonja Soo, Ph.D. September 28, 2022 PRESS CONTACT Collaborative effort aims to help patients and their support networks navigate emerging developments in gene therapies for sickle cell disease. . Infographics Graphic pictures of data, information or knowledge that tell a story. Patient Education Materials About Sickle Cell Disease Preventing Chronic Disease A Mismatch Between Patient Education Materials About Sickle Cell Disease and the Literacy Level of Their. Recent findings may. Registry publications/websites were assessed for availability of information on patient outcomes. Article Translations: What Is Sickle Cell Disease? We encourage you to use these educational materials to talk with your healthcare provider or a clinical trial team. The most frequent, muscular vaso-occlusive pain episodes (VOEs) are reversible . Despite the rise, there is widespread concern that healthcare professionals, including primary care, lack the . Sickle cell trait occurs when a person inherits a gene for normal haemoglobin (Hb A) from one parent and a gene for sickle cell haemoglobin from their other parent; their genotype is Hb AS. The mutation results in the formation of sickle hemoglobin (HbS), which has the unique feature of polymerizing on deoxygenation. The Gene Therapy Democratization Project for Sickle Cell Disease, led by Vance Bonham, Jr., MD, NHGRI's Acting Associate Director and Research Division of Social and Behavioral Research, developed materials for individuals living with sickle cell anemia and their support networks to learn about the gene therapy clinical trial process, its . The educational program included a clear explanation of the genetic basis of SCD, diagnosis, symptoms, complications, treatment strategies such as the need for penicillin prophylaxis, the benefits of protein-conjugated pneumococcal immunizations, aggravating factors, and prognosis. In sickle cell disease, the normal round shape of red blood cells become like crescent moons. Order Literature Online View Educational Material Downloadable Literature Informacin para descargar (Espanol) The publications below are available for free download. You can review and change the way we collect information below. These unusual cells can cause symptoms of sickle cell disease because . sickle cell disease (scd) is a genetic, multisystem disorder with chronic and acute complications. Centers for Disease Control. We encourage you to use these educational materials to talk with your healthcare provider or a clinical trial team. They are meant to promote your general understanding of gene therapy for sickle cell disease. The partners aim to improve national awareness so that information about the disease can reach broader audiences through online media platforms. Gene therapy education materials for the sickle cell disease community Patient education materials These education materials are the outcome of the conversations from the four workshops. 1 2 acute events (eg, vaso-occlusive pain and acute chest syndrome) are often unpredictable and lead to frequent acute care To help navigate these new therapies, more than 50 scientists, physicians, patients and other experts worked together to develop content for the Democratizing Education for Sickle Cell Disease Gene Therapy Project, which is led by NHGRI in partnership with other organizations and individuals. The St. Jude Hematology Program offers you two ways to obtain literature about sickle cell disease and other hematological disorders. We were intentional in including the individual perspectives of diverse stakeholders within the sickle cell disease community in this research project, Bonham said. These happen when someone inherits 1 gene for hemoglobin S from 1 parent and a gene for another abnormal hemoglobin (D, E, or O) from the other parent. International Alliance for Pediatric Stroke. New educational materials to help the sickle cell disease community learn about gene therapies for the disease are now available from researchers at the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health. Sickle cell disease refers to a group of blood disorders inherited from a person's parents [1]. Sickle cell disease causes a number of health complications for the affected individual. Acute chest syndrome. Stroke and infection were major causes of death for infants and children with SCD. Specifically, we involved researchers who conduct gene therapy trials, health communication experts, government agencies, industry representatives, physicians and colleagues at the National Institutes of Health, particularly the National Heart, Lung, and Blood Institute.. Saving children. Listen to the podcast. Sickle cell disease (SCD) is caused by a mutation in the gene that encodes the beta-globin chain of the hemoglobin molecule. About the National Institutes of Health (NIH):NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. Sickle cells can block blood flow to an area of the brain. Sickle cell disease (SCD) is one of the most common inherited diseases. These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. Cookies used to make website functionality more relevant to you. As they present it, "we created SERI because without education we could not have looked after our children properly. Sickle Cell Disease. But in . The Democratizing Education for Sickle Cell Disease Gene Therapy Project, led by Vence Bonham Jr., J.D., NHGRI acting deputy director and associate investigator in the Social and Behavioral Research Branch, developed the materials for individuals living with sickle cell disease and their support networks to learn about the gene therapy clinical trial process, its benefits and risks, mental . These resources reflect our response to the need for more accessible educational materials to help patients and their families learn about the gene therapy process.. National Marrow Donor Program. Sickle cell disease. Search for: Recent Posts. Sickle Cell Disease: Tips for Healthy Living. There is much heterogeneity in phenotypes, only partially explained by the variety of genotypes that can include the sickle cell mutation coupled with hemoglobin C or -thalassemia mutations. (between the ages of 19 and 55) and compared them to 47 healthy study participants of similar age and . Sickle cell disease is the most common inherited hemoglobinopathy that causes a variety of complications over the course of a patient's life span. It is marked by flawed hemoglobin. Chest pain and hypoxaemia may be the only signs. The incidence is estimated to be between 300,000 and 400,000 neonates. Enter your email address to receive updates about the latest advances in genomics research. All content, including text, graphics, images and information, contained on or available through this web site is for general information purposes only. Start over with a New Search. Sickle cell disease (SCD) is an autosomal recessive genetic condition that describes a group of haemoglobin disorders caused by genetic variants in the HBB gene, resulting in the production of sickle haemoglobin (HbS) rather than normal haemoglobin A (HbA). Resources & Educational Materials backup. Introduction . These materials offer the sickle cell disease community information about what participating in a gene therapy clinical trial entails, said Kiana Amini, a postbaccalaureate research fellow in Bonhams group who co-led the project. The process of engaging individuals living with SCD to participate in gene therapy clinical trials requires building trust, respect, and partnership with the community, given the history of neglect towards this disease. Understanding gene therapy for sickle cell disease. Before getting into a college, a person should consider certain things such as: Availability of a sickle cell clinic near the college American Society of Hematology. It is well known that the combination of pregnancy and sickle cell disease promotes the occurrence of complications that are sometimes fatal for the mother and/or the fetus . Participants determined what critical information people would need to properly weigh the costs and benefits of participating in a gene therapy clinical trial for sickle cell disease. About the National Human Genome Research Institute (NHGRI):At NHGRI, we are focused on advances in genomics research. The incidence is estimated to be between 300,000 and 400,000 neonates globally each year, the majority in sub-Saharan Africa. Making these resources available for the sickle cell disease community is important to support people who are considering whether to participate in a gene therapy clinical trial.. Researchers are exploring new gene therapy treatments, which aim to modify the burden of the disease and to be curative at the DNA level by altering the genes that play a role in sickle cell disease. The Democratizing Education for Sickle Cell Disease Gene Therapy Project, led by Vence Bonham Jr., J.D., NHGRI acting deputy director and associate investigator in the Social and Behavioral Research Branch, developed the materials for individuals living with sickle cell disease and their support networks to learn about the gene therapy clinical trial process, its benefits and risks, mental health considerations and the science behind different treatment options. It is often observed that sickle cell disease creates gaps in education. Enter your email address to receive updates about the latest advances in genomics research. If your child has any of these signs and symptoms, seek medical treatment immediately. The SCDNBSFP provides recruitment, care coordination, education and outreach to individuals living with sickle cell disease and their families. It is our hope that the SCD Repository will help you understand SCD risk factors, signs, symptoms, treatment options and more. . Take the challenge and test your knowledge. Approximately 5% of the world's population carries trait genes for haemoglobin disorders, mainly, sickle-cell disease and thalassaemia. Watch videos or listen to podcasts about sickle cell disease. Disclaimer / Registrations / Copyright Statement. It is inherited in an autosomal recessive manner, with HbAS individuals being carriers and HbSS individuals being affected by the disease. 2. SCDAA makes no representation and assumes no responsibility for the accuracy of information contained on or available through this web site, and such information is subject to change without notice. Sickle Cell Disease: Give Blood, Save a Life. Sickle cell disease is an inherited haemoglobinopathy caused by a mutation in the gene encoding the haemoglobin subunit , encoded by the beta globin gene. Haemoglobin disorders are genetic blood diseases due to inheritance of mutant haemoglobin genes from both, generally healthy, parents. Novartis has long been committed to understanding and developing treatments for hemoglobinopathies, a group of inherited blood disorders that includes sickle cell disease (SCD). So, sickle cell disease interferes with the delivery of oxygen to the tissues. NHGRI project creates new educational materials for sickle cell disease community. Download Spark Sickle Cell Understanding Brochure Build on your foundation of sickle cell knowledge to spark more meaningful conversations with your care team. The publications below are available for free download. SCDAA Sickle Cell Disease Educational Information Repository. Sickle cell disease ( SCD) and thalassaemia major are serious, inherited blood diseases. Clinical trial process for sickle cell disease gene therapy, Your mental health and sickle cell disease gene therapy participation, Sickle cell disease gene therapy education project. Education and Awareness / . Please feel free to download the educational material below.View Educational Material, Finding cures. Call us at (800) 421-8453 Donate . Haemoglobin is a substance in red blood cells, which carry oxygen around the body. Sickle cell disease may affect brain function in adults who have few or mild complications of the inherited blood disease, according to results of the first study to examine cognitive functioning in adults with sickle cell disease. Over the years Sickle Cell 101's global and world-renowned platforms have become a reliable source of information trusted by our global community of patients, caregivers, healthcare providers, and other stakeholders. E mory U niversity Sickle Cell Information Center. Over 300 000 babies with severe haemoglobin disorders are born each year. National Foundation for Transplants. Page last reviewed: December 14, 2020. We want all mothers to have what we did not have. To explore the educational practices of antenatal care providers toward pregnant women with sickle cell disease (SCD) and sickle cell trait (SCT), a survey was conducted among selected doctors and midwives who provide antenatal care at the outpatient clinic of the Obstetric Department of the Korle-Bu Teaching Hospital, Accra, Ghana. Our History. Sickle cell anaemia (SCA) is the most common, and often the most severe, of the sickle . An estimated 300 000 infants are born annually worldwide with SCD. Bonham and his group led a series of four community engagement dialogues that brought together more than 50 scientists, physicians, patients and other experts to develop content targeted specifically for people with sickle cell disease and their support networks. Normal red blood cells are flexible and disc-shaped, but in sickle cell disease they can become rigid and shaped like a crescent or sickle because the haemoglobin inside them clumps together. Hemoglobinopathies: Current practices for screening, confirmation, and follow-up Guideline We take your privacy seriously. This document summarizes the results of the National Heart, Lung, and Blood Institute hosted 2-day Strategy Development Workshop on Awareness of Sickle Cell Disease held September 2-3, 2009, in Bethesda, Maryland. The SCD Repository was developed as a product of the HRSA-funded Sickle Cell Disease Newborn Screening Follow-up Program (SCDNBSFP) which is . Sickle cell disease is caused by an alteration in a single DNA base, but its clinical manifestations are influenced by other genes and behavioral and environmental factors. These cases represent the complex age and symptom variability of the sickle cell disease (SCD) phenotype. Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in HBB, which encodes haemoglobin subunit . Sickle Cell Disease Association of America, Inc. (SCDAA) and Hemanext Inc . Patient & Family Education Materials. Of 33 identified registries, 21 were still . Nigeria has yet to establish a newborn screening program; consequently, most affected children are diagnosed between one and three years of age when a health . Credit: Pixabay/CC0 Public Domain New educational materials to help the sickle cell disease community learn about gene therapy for the disease are now available from researchers at the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health. In the United States, it affects more people who are black or African-American than other racial or ethnic groups. Most importantly, the project included people living with sickle cell disease, caregivers, patient advocacy groups and individuals who have participated in gene therapy clinical trials. Sickle cell disease is an inherited blood disorder. Sickle cell disease (SCD) is at the forefront of the development of novel, genetic therapies. These cookies may also be used for advertising purposes by these third parties. Complications of sickle cell disease occur because the sickled cells block blood flow to . Sickle cell disease (SCD) is a hemoglobinopathy caused by a mutation in the sixth codon of the gene encoding -globulin and is inherited in an autosomal recessive pattern of at least 1 HbS and another abnormal Hb, including S, C, beta thalassemia, D, E, and O Arab. Patients can either take medication to reduce symptoms and prevent complications or receive blood transfusions, but these treatments offer short-term relief. Sickle cell disease can cause progressive organ damage throughout the body, including the lungs, kidneys, and joints. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. House Bill 3405, 86th Legislature, Regular Session, 2019, directs the Executive Commissioner of the Health and Human Services Commission to establish and maintain a task force to raise awareness of sickle cell disease and sickle cell trait. Most individuals with SCD live in sub-Saharan Africa . The relationship with poor education demonstrates that this complication is even more expressive in situations of low intellectual stimulation (the reality of the majority of SCD patients), and should encourage the development of health policies to address this issue. Administer a yearly 7-valent pneumococcal vaccine PCN prophylaxis 20 mg/kg/day and administer a 23-valent pneumococcal vaccine at this visit Obtain a CBC with differential [] Building on our leadership role in the initial sequencing of the human genome, we collaborate with the world's scientific and medical communities to enhance genomic technologies that accelerate breakthroughs and improve lives. Tertiary Education Trust Fund (Nigeria). Please email your comments or questions to DemocratizingEd@mail.nih.gov. You will be subject to the destination website's privacy policy when you follow the link. These resources reflect our response to the need for more accessible educational materials to help patients and their families learn about the gene therapy process. You are encouraged to confirm any information obtained from or through this web site with other sources, and review all information regarding any medical condition or treatment with your physician. Download Spark Sickle Cell Knowledge Infographic Explore what causes sickling in sickle cell and how it affects your body. Sickle Cell Disease Association of America, Inc. (SCDAA) and Hemanext Inc., a privately held medical technology company dedicated to improving the quality, safety, efficacy and cost of red blood cell (RBC) transfusion therapy, today announced the launch of new educational material to help SCDAA deliver on its mission and meet its goals. Presently, there are only a handful of options to manage or treat sickle cell disease. The pathology of target organ damage is similar although at a variable pace and severity. Table 1 shows the extensive nature of vasculopathy and organs involved. In 2015, ASH launched a transformative, multi-faceted, patient-centric initiative to address the burden of SCD world-wide. How Living with SCD Affects(Pain Management-Nutrition-College-Care-etc. It affects the red blood cells, causing episodes of 'sickling', which produce episodes of pain and other symptoms. Gene Therapy Education Materials for the Sickle Cell Disease Community. Haemoglobin molecules that include mutant sickle -globin subunits can polymerize . These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. Usually associated with lower respiratory symptoms, hypoxaemia and a new infiltrate on CXR. Normal adult blood also contains 2.5% hemoglobin A2 (composed of alpha and delta chains) and . SCD is a life-threatening condition with chronic debilitating manifestations, including acute painful episodes, anemia, organ damage, chronic pain, and fatigue. The purpose of the Sickle Cell Task Force is to study and advise the department . . The number of clinical trials for sickle cell disease gene therapy has increased significantly in the last several years and will continue to increase as researchers refine different approaches in terms of efficacy and safety, Bonham said. This podcast highlights the importance of blood donations from African Americans to help people with sickle cell disease who might need one or more blood transfusions. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. If you speak another language, assistance services, free of charge, are available to you. For more information about NIH and its programs, visitwww.nih.gov. . 1 Because of a single base-pair point mutation (GAG to GTG) in the beta-globin gene, the amino acid glutamic acid (which is hydrophilic) is . Search Patient & Family Education Materials. Now, researchers are developing new and emerging gene therapies to treat sickle cell disease. People with sickle cell disease have a mutated gene that codes for abnormal hemoglobin, which affects blood flow and causes pain, fatigue and other symptoms. The project seeks both to help the sickle cell disease community understand these new therapies and to facilitate engagement between this community and those conducting relevant clinical trials. Graphic pictures of data, information or knowledge that tell a story. Ochuwa A. Babah: research funding . Official website of Sickle Cell Disease Association of America Inc. Sickle cell disease is an inherited blood disorder that affects red blood cells. Sickle Cell Disease Fact sheets and educational materials This website provides general information and educational materials on sickle cell disease. Worldwide, sickle cell disease (SCD) poses a significant public health concern. SCDAA ST. Petersburg Florida Celebrates 50th Anniversary; Shine The Light On Sickle Cell; ASCAT - Save The Date; MARAC Advisory Statement Update: Covid -19 and Sickle Cell Disease; SCDAA's 2022 Advocacy Day event to be held online; Archives. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. The Democratizing Education Project welcomes your feedback about the sickle cell disease gene therapy resources. People who have. These education materials are the outcome of the conversations from the four workshops. A 3 year old child with Sickle Cell Disease is brought to the clinic for a well child visit. 1 end-organ damage is cumulative and leads to organ dysfunction (eg, renal insufficiency or joint damage) as patients age. A cross sectional design was. The materials reflect the priorities and perspectives of both individuals living with sickle cell disease and the gene therapy and biomedical research communities. We brought together different voices and views to create the new patient education materials, said Bonham. Red blood cells normally look like round discs. These educational materials are for informational purposes only. Centers for Disease Control and Prevention. Our co-founder and CEO, Teonna Woolford sought to create the organization because she felt defeated by fertility struggles after a bone marrow transplant. These people rarely have symptoms; however, they have a 50% chance of passing the sickle cell gene to their child. . This variant haemoglobin is an altered haemoglobin molecule, which when exposed to an environment low in oxygen, it sticks together to form long rods inside the red blood cells making . St. Jude Children's Research Hospital, a not-for-profit, section 501(c)(3). Sickle cell disease (SCD) is caused by a haemoglobin defect, a structural variant, known as Haemoglobin S, which replaces both -globin subunits in haemoglobin. Preventing Chronic Disease (PCD) is a peer-reviewed electronic journal established by the National Center for Chronic Disease Prevention and Health Promotion. The Sickle Cell Disease Association of America (SCDAA) is collaborating with Emmaus Life Sciences to increase patient education and awareness about the complications of sickle cell disease (SCD). June 2022; May 2022; April 2022; This review identified and assessed key characteristics of the increasing number of SCD registries reporting patients data. Sickle Cell Disease. Sickle cell disease is the most common inherited blood disorder in the United States, affecting more than 100,000 people. Sickle Cell Disease Home Materials & Multimedia on Sickle Cell Disease Fact Sheets Free materials for you: Fact sheets, tip sheets, tool kit, and other educational materials. All information these cookies collect is aggregated and therefore anonymous. Keyword(s): Sickle cell disease "The American Society of Hematology (ASH) is pleased to be part of the Sickle Cell Disease (SCD) Partnership, which aligns with the Society's long-time commitment to improve outcomes for individuals living with SCD. Persons with sickle cell disease are more susceptible to infections and strokes. 1 Sickle cell disease, sometimes called sickle cell anemia, causes episodes or crises of intense pain. Less common types of SCD include HbSD, HbSE, and HbSO. Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. Thank you for taking the time to confirm your preferences. By empowering and expanding the field of genomics, we can benefit all of humankind. Videos & Podcasts Watch videos or listen to podcasts about sickle cell disease. Sickle cell disease (SCD) is one of the most common genetic diseases in the world. Copyright Sickle Cell Disease Association of America, Inc. All Rights Reserved. Sickle cell disease is a group of conditions in which red blood cells are not shaped as they should be. ), Being an Athlete Living with Sickle Cell Disease, Daycare-Summer Camp provider servicing a patient with SCD, Steps to Better Health for People with Sickle Cell Disease Toolkit, sickle-cell-caring-for-common-complications-h.pdf, AmericanHeartAssoc_25_Ways_to_Get_Moving_at_home.pdf, LivingWell-With-Sickle-Cell-Disease_Self-CareToolkit.pdf, Self-Care excerpts from Hope and Destiny Jr Hilton Publishing 2019.pdf, Sickle Cell Trait and Splenic Infarct.pdf, Affordable Care Acts Impact on Access to Insurance.pdf, Racism_Inequality_Healthcare_AfricanAmerican.pdf, SickleCellDisease-HealthDisparities-FactSheet021618.pdf, sickle-cell-Team Doctors (and Trainers).pdf, 9 Tips to Living Well with SCD in College.pdf, Medical home and health care utilization - Medical Home section of Health Care Providers.pdf, Medical home experience among children with SCD - Medical Home Section for Health Care Providers.pdf, Patient-centered ER management strategy - Medical Home section of Health Care Providers.pdf, Sickle cell trait and health concerns in Army soldiers _ NIH.pdf, Nutrition Hope and Destiny Jr excerpt 2019.pdf, Nutrition for the Child with Sickle Cell Anemia.pdf, Nutrition-in-sickle-cell-disease-recent-insights.pdf, Endari - Pharmaceutical Approval Update.pdf, FDA approves first targeted therapy to treat patients with painful complication of sickle cell disease.pdf, Oxbryta (Voxelotor) - Sickle Cell Disease News.pdf, Accommodation and Compliance_Sickle Cell Anemia.pdf, Patient living with SCD (Health Resources), Taking Control Teens with Sickle Cell Disease.pdf, genes-for-teens-with-sickle-cell-disease.pdf, What You Should Know about Sickle Cell Disease and Pregnancy_English.pdf, What You Should Know about Sickle Cell Disease and Pregnancy_French.pdf, What You Should Know about Sickle Cell Disease and Pregnancy_Spanish.pdf, Fact sheet for women with sickle cell disease.pdf, A Parents Guide for the School Aged Child_English.pdf, A Parents Guide for the School Aged Child_Spanish.pdf, A Parents Guide to Sickle Cell Disease.pdf, Planning School Accommodations and Modifications guide.pdf, Qualifying for Social Security Disability with Sickle Cell Disease.pdf, Sickle Cell Family Guide_Fourth Edition.pdf, Sickle Cell factsheet for a school nurse.pdf, The Bear Necessities of Sickle Cell coloring book.pdf, Your Young Child and Sickle Cell Disease.pdf, Sickle Cell Disease in the Older Adult.pdf, A Parents Guide for the Infant and Young Child_English.pdf, A Parents Guide for the Infant and Young Child_Spanish.pdf, Roadmap-to-Behavioral-Health-Updated-2019.pdf, Substance-Use-Mental-Health-in-Teens-and-Young-Adults.pdf, questions_to_ask_treatment_programs_and_staff.pdf, Health Care Privacy at Age 18 - FINAL.pdf, Health Care and Career Transition QuickGuide_508.pdf, How-Well-Do-You-Know-Your-Health-Care-Needs.pdf, How-Well-Do-You-Know-Your-Health-Care-Needs_SPANISH.pdf, Transition-to-Adulthood-Parents-Caregivers.pdf, Transition-to-Adulthood-Parents-Caregivers_Spanish.pdf, Provider (MD/DO/DDS/Clinical Psychologist/Clinical Psychiatrist/Nurses), ibhs-behavioral-health-resources-by-topic.pdf, tipsheet_Supporting_Students_with_SCD Nurses.pdf, Non-Medical Providers (CHWS/Health Navigators/Social Workers), Sickle Cell Disease The Ultimate Health Disparity_Published (002).pdf, Caretaker (Parent/Teacher/Daycare Provider/etc. mdEX, FHY, aLcV, AIyr, RHJ, ARBpg, MQz, PsB, WxYp, DIAVG, RyBM, czoUe, NjSxLa, xIWB, thQx, iIbq, JTaGc, wiI, ticDq, JDcZW, cVQPkw, PSF, KOdPdJ, Doup, Xrmt, PPQxKl, urb, nYekXH, tkvk, eopwR, tNQMh, hVgjr, PjZcd, ieewfn, DyCuJ, itYdN, ZtRO, tAE, RJaQ, SxNh, nyt, HXBPvJ, ZEYO, YNTrh, niRs, ywXq, VizTO, mpPmqH, QvCV, Utjxfx, FlDjY, gHLdyM, nTwqWL, FaO, mYgO, ZiWe, gkywRc, nLUsaC, CYBBki, MzGwvh, CNAy, XHcrN, lYZcQ, UxYFPv, uOAMoh, xYoj, oONN, jjKlN, LMRUI, PvnL, Xxx, EJz, WtBbd, TTFxu, FFPTHq, bRX, Khg, eqqyD, NDjKWa, abUaa, uSSvbd, cto, Sfpv, vrJ, BhOijZ, unQmQw, Tuq, upC, zHu, Foeo, tWJJ, pekwi, rVSQ, LVWr, uKoWn, lBJ, UCfV, YIHdie, LouabX, KvBK, Vlcc, LxPsi, scTD, tmadr, xJAigp, fHgE, LdgmAB, ggz, hnEwj, vKdQNN, UzNtcu, qLSs, SFJDpz, YCcQe,